Sun, 8 May 2022, 07:30

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#	Tim	M	M	S	K	SG	GOL	Poin	5 Terakhir
1	Philadelphia Union	37	21	11	5	+49	79:30	74	W W L D D
2	CF Montreal	36	21	5	10	+13	66:53	68	W W D W W
3	New York City FC	37	18	7	12	+19	64:45	61	L W W W D
4	New York Red Bulls	35	15	8	12	+8	51:43	53	L D W W D
5	FC Cincinnati	36	13	13	10	+8	66:58	52	L D L W W
6	Inter Miami	35	14	6	15	-12	47:59	48	W W W L L
7	Orlando City SC	35	14	6	15	-11	44:55	48	W W L W L
8	Columbus Crew	34	10	16	8	+5	46:41	46	L L L D W
9	Charlotte FC	34	13	3	18	-8	44:52	42	W L D L W
10	New England Revolution	34	10	12	12	-3	47:50	42	L L W L W
11	Atlanta United FC	34	10	10	14	-6	48:54	40	L D L L W
12	Chicago Fire	34	10	9	15	-9	39:48	39	L D L L L
13	Toronto FC	34	9	7	18	-17	49:66	34	D W L L L
14	DC United	34	7	6	21	-35	36:71	27	L L L W L

#	Tim	M	M	S	K	SG	GOL	Poin	5 Terakhir
1	Philadelphia Union	17	12	5	0	+40	49:9	41	W W L D D
2	New York City FC	17	10	4	3	+18	37:19	34	L W W W D
3	Inter Miami	17	10	3	4	+6	34:28	33	W W W L L
4	Charlotte FC	17	10	1	6	+12	28:16	31	W L D L W
5	CF Montreal	17	9	3	5	+9	30:21	30	W W D W W
6	Atlanta United FC	17	8	5	4	+7	31:24	29	L D L L W
7	Columbus Crew	17	7	6	4	+7	22:15	27	L L L D W
8	New England Revolution	17	7	6	4	+6	22:16	27	L L W L W
9	Orlando City SC	17	9	0	8	-2	26:28	27	W W L W L
10	FC Cincinnati	17	6	6	5	+10	37:27	24	L D L W W
11	Toronto FC	17	7	3	7	+1	30:29	24	D W L L L
12	New York Red Bulls	17	6	5	6	+4	26:22	23	L D W W D
13	Chicago Fire	17	6	5	6	+1	18:17	23	L D L L L
14	DC United	17	4	4	9	-12	22:34	16	L L L W L

#	Tim	M	M	S	K	SG	GOL	Poin	5 Terakhir
1	CF Montreal	17	11	2	4	+4	33:29	35	W W D W W
2	New York Red Bulls	17	9	3	5	+5	24:19	30	L D W W D
3	Philadelphia Union	17	7	5	5	+6	23:17	26	W W L D D
4	FC Cincinnati	17	6	7	4	-2	27:29	25	L D L W W
5	New York City FC	17	6	3	8	-2	20:22	21	L W W W D
6	Orlando City SC	17	5	6	6	-7	18:25	21	W W L W L
7	Columbus Crew	17	3	10	4	-2	24:26	19	L L L D W
8	Chicago Fire	17	4	4	9	-10	21:31	16	L D L L L
9	New England Revolution	17	3	6	8	-9	25:34	15	L L W L W
10	Inter Miami	17	4	3	10	-15	13:28	15	W W W L L
11	Atlanta United FC	17	2	5	10	-13	17:30	11	L D L L W
12	Charlotte FC	17	3	2	12	-20	16:36	11	W L D L W
13	DC United	17	3	2	12	-23	14:37	11	L L L W L
14	Toronto FC	17	2	4	11	-18	19:37	10	D W L L L

Jika dua tim atau lebih memiliki poin yang sama, kriteria berikut diterapkan: